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If you are vomiting blood, passing black tarry stools, or have become confused and drowsy, seek emergency care now. Bleeding from varices and liver failure are emergencies. Also seek urgent care for severe abdominal pain with distension or fever.

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Liver cancer: treatment when the liver itself is diseased

Most liver cancer arises in a liver already damaged by chronic hepatitis or cirrhosis. That is what makes it different from other cancers — the treatment must consider both the tumour and the liver it grows in.

Hepatitis B and C remain widespread across several of the countries our patients travel from, and both are now treatable. A number of people who contact us about liver cancer turn out to need antiviral treatment and surveillance rather than cancer treatment.

Usually arises in
A damaged liver
Hepatitis B or C, or cirrhosis
Liver function matters
As much as the tumour
Child-Pugh and MELD scores guide what is safe
Transplant
Legally restricted
Near-relative living donor only for foreign nationals
Time in India
3 to 6 weeks
Longer for transplant assessment and surgery
The condition

What liver cancer involves

Hepatocellular carcinoma is the commonest primary liver cancer and typically develops in a liver scarred by long-standing hepatitis B, hepatitis C, alcohol or fatty liver disease. Cholangiocarcinoma arises from the bile ducts and behaves differently. Cancer that has spread to the liver from elsewhere — most often from the bowel — is a separate situation with a separate treatment path.

What distinguishes primary liver cancer from most other cancers is that the organ is usually already failing. Removing a section of a healthy liver is well tolerated; removing the same section from a cirrhotic liver may precipitate liver failure. Treatment decisions therefore depend on two assessments — the tumour, and how much functional reserve the liver has.

This is why scoring systems for liver function are used alongside tumour staging, and why the same tumour may be resectable in one patient and not in another.

The encouraging part is prevention. Hepatitis B can be suppressed with tablets and prevented by vaccination. Hepatitis C is curable in most cases with a course of direct-acting antivirals. Both reduce the risk of liver cancer substantially, and both are available and increasingly affordable.

Symptoms

Symptoms and warning signs

Common symptoms
  • Pain or a dragging discomfort in the upper right abdomen
  • Unexplained weight loss and loss of appetite
  • Abdominal swelling from fluid
  • Yellowing of the eyes or skin
  • Persistent tiredness
  • Feeling full quickly after small meals
  • Often no symptoms at all when found on surveillance scanning
Warning signs of an emergency
  • Vomiting blood or passing black tarry stools
  • Confusion, drowsiness or disorientation
  • Severe abdominal pain with distension and fever
  • Rapidly deepening jaundice
  • Breathlessness with a swollen abdomen
  • Fever during chemotherapy

If you have hepatitis B or C, treat it — and be scanned regularly

Chronic hepatitis B suppressed with antiviral tablets, and hepatitis C cured with a course of direct-acting antivirals, both substantially reduce the risk of liver cancer. And where cirrhosis is already present, six-monthly ultrasound surveillance detects cancers at a stage when they can still be cured. A number of patients who contact us about a liver mass turn out to need antiviral treatment and surveillance rather than cancer treatment — and that is a far better outcome.

Diagnosis

How it is diagnosed

Liver cancer is unusual in that imaging alone can often make the diagnosis, without a biopsy.

Initial tests

  • Ultrasound of the liver — the surveillance test in patients with cirrhosis
  • Alpha-fetoprotein (AFP) — a blood marker, raised in many but not all liver cancers
  • Liver function tests and clotting — with albumin and bilirubin, used to score liver reserve
  • Hepatitis B and C testing — including viral load where positive

The deciding tests

  • Triple-phase CT or MRI of the liver — the characteristic pattern of contrast uptake and washout can diagnose hepatocellular carcinoma without biopsy
  • Child-Pugh and MELD scoring — quantifies liver reserve and determines what treatment is safe
  • Endoscopy — checks for varices in the oesophagus, which need treating before major surgery
  • Biopsy — used where imaging is not diagnostic, or for suspected cholangiocarcinoma

Send the liver function tests, not only the scan

Two patients with identical tumours can need entirely different treatment depending on how well their livers are working. We need bilirubin, albumin, INR or prothrombin time, platelet count, and whether there is fluid in the abdomen or any history of confusion. Together these determine what can safely be done. A scan without them tells only half the story.

Options

Treatment options

Options depend on tumour size and number, and on liver function. Several are catheter-based rather than surgical.

Option one

Surgical resection

Removing the segment of liver containing the tumour. It offers the best outcome where the tumour is confined and the liver has enough reserve to tolerate losing part of itself. In a well-preserved liver the remaining tissue regenerates substantially over the following weeks.

Usually appropriate whenA single tumour, or limited disease, with well-preserved liver function and no significant portal hypertension.
Option two

Ablation

Destroying the tumour with heat delivered through a needle placed under imaging guidance — radiofrequency or microwave ablation. For small tumours it can achieve results comparable to surgery with far less physiological stress, which matters greatly in a cirrhotic liver.

Usually appropriate whenSmall tumours, typically under three centimetres, particularly where liver reserve is limited.
Option three

Transarterial chemoembolisation or radioembolisation

A catheter delivers chemotherapy or radioactive microspheres directly into the artery feeding the tumour while blocking its blood supply. It controls disease rather than curing it, and is often used for multiple tumours or as a bridge while awaiting other treatment.

Usually appropriate whenMultiple tumours confined to the liver, with preserved liver function, where resection and ablation are not feasible.
Option four

Liver transplant — and its legal limits

For selected small tumours in a cirrhotic liver, transplant treats both the cancer and the underlying liver disease and offers the best long-term outcome. For foreign nationals in India, this requires a living donor who is a near relative, with the relationship certified by your embassy and the case approved by a hospital Authorisation Committee. We cannot find, source or arrange a donor, and nobody legally can.

Usually appropriate whenSmall tumours within accepted criteria, in a cirrhotic liver, where a near-relative living donor is available and legally documented.
The decision

How the choice is made

Tumour size, number and vascular involvement

A single small tumour has many options. Multiple tumours or invasion of the portal vein narrow them considerably.

Liver function reserve

Child-Pugh and MELD scores determine what the liver can survive. This is why the blood tests matter as much as the scan.

Whether a legally eligible living donor exists

For transplant, this is decided by law before it is decided by medicine. Read the transplant page before making any plans.

Where the underlying hepatitis has not been treated, treating it is part of treating the cancer — and occasionally it turns out to be the main thing that was needed.

Urgency

How urgent is your case

Usually safe to plan travel
  • Stable, no jaundice or confusion
  • Compensated cirrhosis under follow-up
  • Tumour found on surveillance while well
  • Planning assessment for resection or ablation
Needs local assessment before travel
  • Vomiting blood or black stools
  • Confusion or drowsiness
  • Deepening jaundice
  • Tense abdominal swelling with fever
  • Kidney function deteriorating

We will tell you which column you are in

Decompensated liver disease — bleeding, confusion, or uncontrolled fluid — needs stabilising locally first. Flying with it is not safe and no assessment here can proceed until it is controlled.

Next step

What to send us

Photographs taken on your phone are fine. Reports in Arabic, Russian or Bengali are fine — we translate them ourselves.

Most useful

  • Triple-phase CT or MRI of the liver
  • Liver function tests — bilirubin, albumin, INR, platelets
  • Alpha-fetoprotein result
  • Hepatitis B and C status with viral load

Also helpful

  • Ultrasound reports and any earlier scans for comparison
  • Endoscopy report if performed
  • Biopsy report if a biopsy was done
  • Details of alcohol history and any previous liver treatment
Questions

Questions patients ask

Yes, in the right circumstances. A single small tumour in a liver with good function can be cured by resection, ablation, or transplant. The difficulty is that many liver cancers are found late, in livers already failing, which narrows the options. Surveillance scanning in people with cirrhosis is what finds them early enough to cure.

Only with a living donor who is a near relative, whose relationship is certified by your embassy, and with approval from a hospital Authorisation Committee. Deceased-donor organs are not accessible to foreign nationals. We cannot find or arrange a donor for you — that is illegal and anyone offering it should be avoided. Where you do have an eligible family donor, living-donor liver transplant is performed to a high standard in Delhi NCR.

Almost certainly yes, and it should be discussed as part of your cancer plan. Curing hepatitis C improves liver function, reduces the risk of new tumours developing, and may make other treatments safer. Direct-acting antivirals cure most patients with a course of tablets and are far more affordable than they once were.

It is a score combining bilirubin, albumin, clotting, fluid in the abdomen and any history of confusion, and it grades how well your liver is functioning. It matters because it determines what treatment your liver can survive. Two patients with identical tumours may need completely different treatment because of it.

Yes, and it is often correct. Hepatocellular carcinoma has a characteristic appearance on triple-phase CT or MRI — enhancing in the arterial phase and washing out later — which in a patient with cirrhosis is diagnostic without a biopsy. Biopsy carries a small risk of seeding and is reserved for cases where imaging is not conclusive.

Hepatitis B vaccination is highly effective and should be given to all close family members who are not already immune. Anyone in the family with chronic hepatitis B or C should be assessed for treatment, and those with cirrhosis should have six-monthly liver ultrasound surveillance. These measures prevent far more liver cancer than any treatment cures.

Contact

Send us your reports

Send the triple-phase CT or MRI together with liver function tests and your hepatitis status. All three are needed before anyone can advise you properly.

Your reports go directly to our medical team. We do not share your records with hospitals until you tell us to.

WhatsApp +91 83035 86344  ·  Phone +91 83035 86344  ·  Email tibhind@gmail.com

Coordinators available 9:00–20:00 IST. We speak Arabic, English, Russian and Bengali.