Chronic kidney disease is staged from one to five by the estimated glomerular filtration rate. Stage five, below fifteen, is end-stage — the kidneys can no longer sustain life unaided.
The commonest causes worldwide, and across the countries our patients travel from, are diabetes and high blood pressure. Glomerulonephritis, polycystic kidney disease, obstruction and repeated infection account for much of the rest. In some patients no cause is ever identified because the kidneys are already too shrunken to biopsy by the time they are examined.
Dialysis sustains life but replaces only a fraction of normal kidney function. Haemodialysis typically means three sessions a week of four hours each, with fluid and dietary restriction between them, and it constrains work, travel and family life considerably. Peritoneal dialysis offers more independence but has its own demands.
Transplant is better on almost every measure — longer survival, more energy, fewer restrictions, and a life not organised around a machine. It is not a cure, and it commits you to immunosuppressive medication for life with regular monitoring. But for most patients who are suitable, it is transformative.